Advanced Formulation Design for Topical Creams Assisted with Vibrational Spectroscopic Imaging

Vibrational spectroscopic imaging has become useful analytical tools for quality control of drug products. In this study, we applied microscopic attenuated total reflection (ATR)-IR and confocal Raman microscopy to elucidate structure creams the formulation design in development semi-solid The model were prepared with prednisolone (PRD) fluconazole (FLC) as active pharmaceutical ingredients oily solvents such mineral oil (MO), isopropyl myristate (IPM), benzyl alcohol (BA) diethyl sebacate (DES). As a result ATR-IR imaging, several domains indicating internal phase observed, which had absorption around 1732 1734 cm−1 derived from MO, IPM DES. addition, BA 1009 observed at complemental or similar position MO DES, respectively. These results suggested that oil-in-water type distribution would reflect compatibility solvents. contents PRD determined quantitatively each layer after intentional separation agreed well analysis. Whereas, allowed visualize components depth direction two-dimensional plane. particular, ensure coexistence FLC cream. From these results, feasibility techniques was successfully demonstrated dosage forms.